dihexa peptide

Dihexa (N-hexanoic-Tyr-Ile-(6, PNB-0408) aminohexanoic amide.
Dihexa is a peptide and nootropic  that has been developed by researchers from Washington State University.


Dihexa is concentrated in multiple brain regions. Rats fitted with a carotid cannula were anesthetized and infused with 0.5 ml of isotonic saline containing 10 mCi of [ 3 H]dihexa and 2 mCi of [ 14 C]inulin, a vascular marker. Thirty minutes after infusion, the rats were decapitated, the brains were removed, and various brain regions were dissected. The tissues were then weighed and solubilized with NCS tissue solubilizer, an organic protein solubilizing agent, and 10 ml of scintillation was added. Samples were counted with a scintillation counter using two different windows to quantitate both 3 H and 14 C counts. 3 H / 14 C ratios were determined so that blood-derived dihexa contamination of tissues could be determined. The results indicate that all brain regions concentrated dihexa (P , 0.001) compared with blood, but no area was statistically different from any other (P. 0.05). The average 3 H / 14 C ratio for blood was 1687 (mean 6 S.E.M.; n = 4). Counts Per Minute (CPM), XXXX.